The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers
Article Abstract:
The genes for AmpG beta-lactamase from Citrobacter freundii were introduced into Escherichia coli and induced to mutate into four different mutations. These four mutants were unable to exhibit limited capabilities to produce beta-lactamase in response to beta-lactam antibiotics. Nucleotide sequencing of the mutant genes revealed substitutions of aspartate for glycine, or the presence of the wild-type gene with limited expression. These mutations reverted to the wild type after spontaneous back-mutation.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1995
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Antibacterials that are used as growth promoters in animal husbandry can affect the release of Shiga-toxin-2-converting bacteriophages and Shiga toxin 2 from Escherichia coli strains
Article Abstract:
Ability of growth-promoting antibiotics to bring on Shiga-toxin (Stx)-converting bacteriophages from Stx-producing Escherichia coli (STEC) strains in farm animals has been studied. Tylosin and monensin cut down on phage induction. Production of Stx increased /decreased in proportion to free phages.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2000
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The signal transducer (BlaRI) and the repressor (BlaI) of the Staphylococcus aureus beta-lactamase operon are inducible
Article Abstract:
Results indicate that the promoters for both the signal transducer/repressor blaRI/blaI as well as their mRNA are inducible. Data point out that the promoters also synthesize chloramphenicol acetyltransferase.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2001
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