The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
Article Abstract:
Small GTP-binding proteins, Rac1 and Cdc 42, regulate the activity of c-Jun amino-terminal kinase (JNK), indicating that these proteins play an important role in JNK signaling pathway. Mitogen-activated protein kinases (MAPKs) are protein-serine or threonine kinases activated by the stimulation of many cell surface receptors. JNKs and MAPKs are related proteins though regulated by different stimuli. Another class of MAPKs, the stress-activated protein kinases (SAPKs) can phosphorylate the c-Jun amino terminus, so SAPKs are called JNKs.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1
Article Abstract:
The pp70 S6 kinase (pp70S6k) signaling cascade is regulated by the Rac1 Rho G proteins and Cdc42 during the process of oncogenesis. The induced fibroblast transformation by the oncogenic p21ras requires Rac1 activity. The activation of endogenous Cdc42 by Dbl nucleotide exchange factor expression is mediated by pp70S6k. The Rho family G proteins also regulates a serine/threonine kinase during cell proliferation. Cdc42 and Rac1 interacts with pp70s6k in a guanine triphosphate-dependent manner.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
Article Abstract:
The inducible, tetracyline-regulated expression in two cell types have been examined to determine the functional properties of BRC1 and to find out how it affects endogenous target genes. Results suggest that BRCA1 expression targets the DNA damage-responsive gene GADD45. This interaction has been found to activate the c-Jun N-terminal kinase/stress-activated protein kinase pathway that triggers apoptosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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