Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex

Article Abstract:

The biochemical purification of Toca-1 (transducer of Cdc42-dependent actin assembly) as an essential component of the Cdc42 pathway is described. It is found that in this model, activated Cdc42 interacts with both Toca-1 and the N-WASP-WIP complex, and these interactions lead to the activation of N-WASP, which in turn stimulates actin nucleation through the Arp2/3 complex.

Actin, Nucleation, Nucleation (Chemistry)

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Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs

Article Abstract:

Researchers conducted tests to show that Rdp1 is associated with two proteins, Hrr1, which is an RNA helicase, as well as with Cid12, which is a member of the polyA polymerase family. The findings suggest that there is a physical as well as a functional link between Rdp1 and RITS.

RNA polymerases, RNA interference

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