Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development
Article Abstract:
Mice lacking p45, the hematopoietic subunit of the transcription factor NF-E2 exhibited no platelet formation within their megakaryocytes during hemorrhage. However, serum levels of thrombopoietin/megakaryocyte growth and development factor (MGDF) remained unchanged despite the absence of platelets. As promoter of the maturation and proliferation of megakaryocyte precursors, the continuous production of MGDF assures megakaryocyte development and platelet production.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages
Article Abstract:
The hematopoietic potential of homozygous mutant SCL/tal-1 -/- embryonic stem cells in chimeric mice is studied to define roles in other lineages. Hematopoiesis is shown to be undetectable in the absence of SCL/tal-1. This includes the generation of red cells, myeloid cells, mast cells, megakaryocetes and both T and B lymphoid cells. Such results suggest that SCL/tal-1 functions in the early stages of hematopoietic development.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Chipping away at the embryonic stem cell network
Article Abstract:
Critical transcription factors, notably OCT4, SOX2, and NANOG are necessary to maintain self-renewal and pluripotency, two properties characteristic of embryonic stem (ES) cells. The findings indicate the presence of a complex network of autoregulatory and feedward loops in human ES cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. The prepattern transcription factor Irx3 directs nephron segment identity
- Abstracts: Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Histone lysine demethylases and their impact on epigenetics
- Abstracts: Identification of bacteria potentially responsible for oxic and anoxic sulfide oxidation in biofilters of a recirculating mariculture system
- Abstracts: Fluorescence in situ hybridization-flow cytometry-cell sorting-based method for separation and enrichment of type I and type II metanotroph populations
- Abstracts: Potential role of pathogen signaling in multitrophic plant-microbe interactions involved in disease protection