Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
Article Abstract:
Mcl-1 is ubiquinated at five lysines and a 482 kDa HECT-domain-containing ubiquitin ligase named Mule (Mcl-1 ubiquitin ligase E3) that is both required and sufficient for the polyubiquitination of Mcl-1 is identified. Mule is a unique BH3-comtainingE3 ubiquitin ligase apical to Bcl-2 family proteins during DNA damage-induced apoptosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis
Article Abstract:
A mutation in GLD-1, a translational repressor implicated in multiple C. elegans germ cell fate decisions and related to mammalian Quaking proteins is identified in a genetic screen for negative regulators of CEP-1. The regulation of cep-1/p53 translation influences DNA damage-induced apoptosis is revealed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis
Article Abstract:
A mutation in GLD-1, a translational repressor implicated in multiple C. elegans germ cell fate decisions and related to mammalian Quaking proteins is identified in a genetic screen for negative regulators of CEP-1. The regulation of cep-1/p53 translation influences DNA damage-induced apoptosis is revealed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
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