Slugging it out: Fine tuning the p53-PUMA death connection
Article Abstract:
The transcription factor SLUG is induced by p53 protects hamatopoietic progenitor cells from apoptosis triggered by DNA damage. The SLUG exerts the protective role by repressing puma, a proapoptotic target of p53 and is also key coordinator of apoptosis mediated by both nuclear and cytoplasmic functions of p53.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
United States, Messenger RNA
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR
Article Abstract:
The mouse p18 loss-of-function phenotype and a role for p18 in the DNA damage response are described. Results show that p18 is a haploinsufficient tumor suppressor and a key factor for ATM/ATR-mediated p53 activation.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Phenotype, Phenotypes, Transfer RNA
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Subjects list: Research, DNA damage, Tumor suppressor genes, Tumour suppressor genes
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