Yeast KRE2 defines a new gene family encoding probable secretory proteins and is required for the correct N-glycosylation of proteins
Article Abstract:
A new gene family encoding secretory proteins from Saccharomyces cerevisiae was discovered following the analysis of KRE2 gene and the subsequent discovery of two other genes. KRE2 gene was isolated by using functional complementation of a killer-resistant allele and was localized at a region near PHO8 on chromosome. Two other genes were identified as YUR1 and KTR1. YUR1 was found on chromosome 10 and encoded a protein product that contained an N-terminal signal sequence similar to the protein product of KRE2 gene. KTR1 was located on chromosome 15 and the topology of its protein product conformed with a type 2 membrane protein.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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A mutational analysis of killer toxin resistance in Saccharomyces cerevisiae identifies new gene involved in cell wall (1-6)-beta-glucan synthesis
Article Abstract:
Three genes which functions in cell wall (1-6)-beta-glucan synthesis were identified. The KRE9, KRE10 and KRE11 genes were identified through their resistance to the Saccharomyces cerevisiae K1 killer toxins. Analyses showed that mutations in KRE11 and KRE9 genes resulted in decreased levels of (1-6)-beta-gulcan in the yeast cell walls. Structural analysis of the resultant phenotype in the kre11 mutant revealed a structure smaller than the wild-type glucan polymer. The study gave insight to the nature of glucan biosynthesis and yeast cell wall synthesis.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1993
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SCK1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase
Article Abstract:
Suppressor of loss of cAMP-dependent protein kinase (sck1) is a cloning product of a new Schizosaccharomyces pombe gene that has properties homologous to the Saccharomyces cerevisiae SCH9 gene. The sck1 gene's suppression behavior generates mutations with less PKA activity. Although high copy number sck1 exhibits such suppression activity, its disruption has no substantial impact on process regulation under PKA control.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1995
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