A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation
Article Abstract:
Mutations in mod(mdg4) enhance the effect of the suppressor of Hairy wing su(HW) protein by inhibiting the function of enhancers located on both sides of the su(HW)-binding region. This inhibition causes a variegated expression pattern, and mutation in mod(mdg4) act as a classical enhancers of position-effect variegation. The mod(mdg4) protein regulates the nature of the repressive effect of su(HW); in the absence of mod(mdg4) protein, su(HW) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4) the silencing effect is transformed into unidirectional repression.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Dominant effects of suppressor of Hairy-wing mutations on gypsy-induced alleles of forked and cut in Drosophila melanogaster
Article Abstract:
A study was conducted to examine the impact of Hairy-wing su(Hw) mutations on gypsy-induced alleles. These forked (f) and cut (ct) loci mutations are often recessive. However, su(Hw) dominates alleles f(super k), ct(super k) and ct(superMRpN30). Molecular analysis of the f allele shows that it is the product of an altered state of octamer-like repeat and su(Hw) product. Mutations for the other alleles also show a correlation between su(Hw) and octamers.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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The suppressor of Hairy-wing protein regulates the tissue-specific expression of the Drosophila gypsy retrotransposon
Article Abstract:
Examination of the function of suppressor of Hairy-wing (su(HW)) protein in gypsy expression in Drosophila melanogaster reveals that during development su(HW) functions as a positive activator of gypsy transcription. Spatial and temporal expression of gypsy requires few other sequences along with su(HW)-binding site. Zinc finger region and two other structural regions of su(HW) are important for the transcriptional regulation of gypsy.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1995
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