Global mapping of pharmacological space

Article Abstract:

Global mapping of pharmacological space by the integration of several vast sources of medicinal chemistry structure-activity relationships (SRA) data is presented. The relationships between proteins, chemical structures and drug-like properties provide a framework for developing a probabilistic approach to drug discovery that could be exploited to increase research productivity.

Analysis, Structure-activity relationships (Pharmacology), Structure-activity relationship (Pharmacology), Pharmacology, Experimental, Pharmacological research

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A human hepatocyte factory

Article Abstract:

A new mouse model is developed that have helped in the expansion of human hepatocytes in vivo. This model has a large impact in the pharmaceutical industry as it is useful for drug-toxicity screening and the development of drugs against chronic hepatitis B and C virus.

Evaluation, Drug therapy, Hepatitis, Viral, Viral hepatitis, Liver cells, Hepatocytes, Drug toxicity

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Network pharmacology

Article Abstract:

Network biology helps in understanding the drug action and provides insights for improving drug discovery for complex diseases. The combination of network biology and chemogenomics enables a new network-pharmacology approach to drug discovery.

Drug targeting, Genomics

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