Toward a universal multistrain bacterial vaccine

Article Abstract:

An approach using multi-strain genome analysis is described to identify a multicomponent protein-containing vaccine that could be used as the basis for a group 'B Streptococcus' (GBS) vaccine with near-universal coverage. GBS is a very common bacterium, found harmlessly colonizing 20-3% of the adult population.

Genetic screening, Genetic testing, Bacterial vaccines, Streptococcus agalactiae

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Microfabricated arrays of femtoliter chambers allow single molecule enzymology

Article Abstract:

A silicone device presenting a large array of micrometer-sized cavities, which is used to tightly enclose volumes of solution, as low as femtoliters, over long periods of time, is described. This was demonstrated by measuring the activity of single molecules of beta-galactosidase and horseradish peroxidase.

Research and Development in the Physical, Engineering, and Life Sciences, Enzymology, Horse-radish, Horseradish, Beta galactosidases

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A universal RNAi-based logic evaluator that operates in mammalian cells

Article Abstract:

The application of small mediator RNA interference (RNAi) in human kidneys to develop a molecular constructing centre that executes general Boolean logic to decide based on endogenous molecular inputs is demonstrated.

Kidneys, Kidney, Algebraic logic, RNA interference

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