siRNA becomes smart and intelligent

Article Abstract:

The first artificial neural network (ANN)-based algorithm for designing small interfering ribonucleic acids (siRNAs) is used in a study to generate a library of siRNAs for more than 24,000 human genes. The algorithm may enable the design of highly specific and efficient siRNAs for any organism, thus providing a powerful tool for RNA interference (RNAi).

Antisense RNA, Organisms

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Design of a genome-wide siRNA library using an artificial neural network

Article Abstract:

A study describes the designing of a genome-wide short interfering ribonucleic acid (siRNA) library using an artificial neural network (ANN)-based algorithm. The algorithm named BIOPREDsi, reliably predicted activity of 249 siRNAs targeting endogenous genes at micro (m) RNA and protein levels.

Usage, Neural networks, Technology application, Neural network

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Rational siRNA design for RNA interference

Article Abstract:

A rational small-interfering ribonucleic acid (siRNA) is presented for studying RNA interference. It is seen that the eight specific determinants of siRNA functionality can be identified and potent siRNA selection can be improved by using algorithm that incorporates all the eight criteria.

Genetic algorithms

Similar abstracts:

• Abstracts: Revealing the world of RNA interference. Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks
• Abstracts: Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
• Abstracts: Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement
• Abstracts: Knockdown by RNAi-proceed with caution. All in the RNA family: Small interfering RNA is targeted to a specific cell type in vivo using an RNA aptamer

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