A lattice protein with an amyloidogenic latent state: Stability and folding kinetics

Article Abstract:

The design of a model lattice protein possessing two low-energy states, native and latent, is presented based on amyloid-fiber-forming protein as the prototype. A simple kinetic model is developed describing the transitions between the characteristic states and the rate constants for the essential transitions assessed and it is proposed that bifurcation may happen for proteins in which native and latent states have a large part of their structures in common.

Analysis, Protein folding, Amyloid beta-protein, Monte Carlo method, Monte Carlo methods, Dynamics, Dynamics (Mechanics), Properties, Structure

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Folding of A three-helix bundle at the folding speed limit

Article Abstract:

It is shown that a double mutant (K51/K39V) of 1prb(sub 7-53), the GA module of an albumin binding domain, has a maximum folding rate constant of ~1(mus)(super -1). The value is comparable to the estimated theoretical speed limit for protein folding. It is found that the mean hydrophobicity of a given tertiary fold plays an important role in controlling its folding rate.

Proteins, Albumin, Hydrophobic effect

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