Incidence of cancer after prophylaxis with warfarin against recurrent venous thromboembolism

Article Abstract:

The risk of cancer after an episode of venous thromboembolism is highest during the following year and then decreases, especially if the patient takes an anticoagulant. Venous thromboembolism occurs when a blood clot forms in the leg veins and then travels to the lungs. In a study of 902 patients with venous thromboembolism, the rate of cancer during the first year was 3.4% but fell to 2 or less in the subsequent years. Patients who took the anticoagulant drug warfarin for six months had a lower rate of cancer than those who took it for six weeks.

Health aspects, Causes of, Cancer, Warfarin

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A comparison of six weeks with six months of oral anticoagulant therapy after a first episode of venous thromboembolism

Article Abstract:

A six-month course of anticoagulant treatment may be more effective in preventing a recurrence of deep vein thrombosis or pulmonary embolism than a six-week course. Deep vein thrombosis and pulmonary embolism occur when a blood clot blocks the veins in the legs or lungs, respectively. Of 897 patients who had been treated for deep vein thrombosis or pulmonary embolism, 443 began taking the anticoagulants warfarin or dicumerol for six weeks and 454 began taking one or the other drug for six months. The six-month treatment cut the risk of a recurrence in half when compared to the six-week treatment. Patients taking six months of anticoagulant treatment were no more likely to suffer a major hemorrhage from the treatment as those taking six weeks of anticoagulant treatment. Mortality rates after two years of follow-up were also similar in the two groups.

Usage, Pulmonary embolism, Thrombosis, Deep vein, Deep vein thrombosis

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The duration of oral anticoagulant therapy after a second episode of venous thromboembolism

Article Abstract:

The long-term use of oral anticoagulants in people with chronic venous thromboembolism appears to reduce the risk of recurrent disease but also increases the risk of hemorrhage. Venous thromboembolism occurs when a blood clot forms in a vein and travels to another part of the body. In a study of 227 people with this condition, 111 took anticoagulants for 6 months and 116 took them indefinitely. After four years, those who took anticoagulants for 6 months had 8 times the risk of a recurrence. However, they had one-third the risk of a major hemorrhage compared to those still taking the drugs.

Risk factors, Hemorrhage, Dosage and administration

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