A role for LEDGF/p75 in targeting HIV DNA integration
Article Abstract:
HIV integration in cells depleted for LEDGF/p75 is presented. The integration showed that LEDGF/p75 is the first example of a cellular protein controlling the location of HIV integration in human cells as the integration was less frequent in transcription units and genes regulated by LEDGF/p75 and more frequent in GC-rich DNA.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Cyclophilin A modulates The sensivity of HIV-1 to host restriction factors
Article Abstract:
The sensitivity to restriction factors that is regulated by cyclophilin A, which is cell protein that bids the HIV-1 capsid protein is examined. Findings indicate that HIV-1 has been appointed to host cell protein to undermine restriction factors expressed by human cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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HIV-1 and Ebola virus: the gateway driver nabbed
Article Abstract:
The author discusses the publications on Tsg101 protein which is a part of the protein trafficking machinery in the healthy heart. Results indicate that HIV-1 and Ebola viruses subvert this protein to exit a cell for renewing their cycles of infection.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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