Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells
Article Abstract:
Doctors may decide future treatment of Hodgkin's lymphoma based on the classification of the patient's Reed-Sternberg cells as either originating from a single or multiple cell line. Reed-Sternberg cells are giant cells typically found in patients with Hodgkin's lymphoma. Researchers analyzed the gene rearrangements of single Reed-Sternberg cells from 12 patients with Hodgkin's disease. They found gene rearrangements in all of the cells studied but with varying patterns. Three of the cell samples had identical gene rearrangements similar to cancer cells originating from a single cell line. The remaining specimens had gene rearrangements that indicated that they came from either multiple or mixed cancer cell lines. Some of the gene rearrangements were similar and some differed in the second set of three cell samples. The last six cell samples all had varying gene rearrangements.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1995
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Hodgkin's disease - new insights from immunoglobulin genetics
Article Abstract:
The distinguishing genetic characteristics of Reed-Sternberg cells in patients with Hodgkin's disease may help shape future treatments of this lymph cancer. Reed-Sternberg cells are giant cells typically found in patients with Hodgkin's disease. A recent study has found that these cells also express a marker for immune cells called B lymphocytes. This characteristic can be useful in identifying the cells as originating from either a single or multiple cell line. The researchers found varying patterns in the cell samples studied. They found single cell lines in three of the eight cell samples and multiple or mixed cell lines in another three samples. Normal B cells originate from multiple cell lines. This data does not suggest that Reed-Sternberg cells are cancerous.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
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