Antibody response to inactivated influenza vaccines of various antigenic concentrations

Article Abstract:

Infection with influenza can lead to serious illness, particularly in elderly people. Vaccination decreases the frequency of infection, but does not appear to be as effective as vaccination against other diseases, such as measles, particularly for the elderly. In order to see if the effectiveness of influenza vaccines could be boosted, 140 people, aged 18 to 64, were inoculated with vaccines containing different doses of standard influenza antigens obtained from inactivated influenza virus (a type of vaccine used in the United Kingdom but not the US). There was increased antibody production in response to increased doses of A/Chile-type antigen, but not to A/Philippines or B/USSR antigens. Antibody levels against these last two antigens were significantly lower among older people. Although this implies that at least some older people will be at higher risk for developing influenza in spite of higher doses of vaccine, other factors may moderate this risk. Further study is needed to evaluate ways of enhancing efficacy of influenza vaccination in the elderly population. (Consumer Summary produced by Reliance Medical Information, Inc.)

Prevention, Demographic aspects, Influenza, Vaccines, Dosage and administration

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Use of seating devices in infants too young to sit

Article Abstract:

Infants too young to sit unsupported may spend large amounts of time in infant seats. The parents of 187 infants less than five months old responded to a questionnaire. Ninety-four percent of the infants spent 30 minutes or more per day in a car/infant seat. The average time per day was nearly six hours, extending to as much as 16 hours. Potential adverse effects of extended time periods in infant seats include reduction in physical contact between mother and baby, falls from tables or counters, increased risk of severe regurgitation, and interference with breathing in sleeping infants.

Care and treatment, Infants, Infant care

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Child restraint device use in patients leaving children's hospital

Article Abstract:

Children's hospitals may need to do more to promote the use of child restraint devices (CRDs) in cars. Researchers surveyed 295 parents with at least one child under the age of four in the parking area of an urban children's hospital. Eighty percent (235) of parents said they used CRDs. Parents who were least likely to use CRDs were nonwhite and received medical care from a public clinic or a specialty clinic. Children aged 24 to 48 months were at risk of not being placed in a CRD. One-fourth of parents used CRDs incorrectly.

Automobiles, Seat belts

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