Antiretrovirals induce direct endothelial dysfunction in vivo
Article Abstract:
The male Sprague-Dawley rats were treated with clinically relevant doses of azidothymidine (AZT) and/or indinavir similar to those administered in humans to determine whether nucleoside reverse transcriptase inhibitors (NRTI) and/or protease inhibitors induce endothelial dysfunction. The findings suggest that in addition to the lipid disorders induced by protease inhibitors and mitochondrial DNA depletion in myocardial cells, direct endothelial dysfunction induced by AZT and perhaps other NRTIs might contribute to the development of cardiovascular complications observed in HIV patients.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
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HIV-1 reverse transcriptase mutants resistant to nonnucleoside reverse transcriptase inhibitors do not adversely affect DNA synthesis: Pre-steady-state and steady-state kinetic studies
Article Abstract:
The polymerase function of 3 clinically occurring nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant RTs in greater detail, under both pre-steady-state and steady-state conditions is evaluated. Results indicate that the close proximity of the NNRTI-resistance mutations to the polymerase active site does not affect the interactions of the enzyme with the incoming nucleotide or the primer-template sufficiently to affect polymerization.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
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Therapeutic drug monitoring of Efavirenz: Trough levels cannot be estimated on the basis of earlier plasma determinations
Article Abstract:
An experiment was conducted to find out whether a limited sampling strategy could provide a good estimation of efavirenz (EFV) trough levels and area under the curve (AUC). The weak association observed between EFV plasma levels and treatment outcomes in the study might explain that no adequate substitute for collecting blood 24 hours after dosing emerged from the analysis.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2005
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