Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis
Article Abstract:
An investigation was carried out to study the direct consequences of vascular smooth muscle cell (VSMC) apoptosis by generating transgenic mice expressing the human diphtheria toxin receptor (hDTR) from a minimal Tagin promoter. Results indicated that VSMC apoptosis is silent in normal arteries, which have a large capacity to withstand cell loss, while in contrast, VSMC apoptosis alone is sufficient to induce features of plaque vulnerability in atherosclerosis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Connexin37 protects against atherosclerosis by regulating monocyte adhesion
Article Abstract:
An insight into the participation of connexin37 (CX37) in antherogenesis affected individuals was obtained on the basis of polymorphic gene association studies and protein expression analysis. Finding show that similar to other chronic inflammatory diseases, the development of antherosclerotic plaques represents a balance between the pro- and anti-inflammatory influences which shows that CX27 protects against excessive monocyte recruitment in antherosclerosis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Fast track to the porphyrins
Article Abstract:
The way calorie restriction affects the production of porphyrin precursors that could trigger an acute attack is demonstrated. The production of excess porphyrin precursors in the liver causes attacks of the acute porphyrias, characterized by episodic neuropathic abdominal pain, peripheral neuropathies, potentially lethal respiratory paralysis and acute psychotic episodes.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: HDAC7 supports vascular integrity. Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
- Abstracts: The economic burden of HIV in the United States in the era of highly active antiretroviral therapy. Increased risk of intrauterine transmission of HIV-1 associated with granulocyte elastase in endocervical mucus
- Abstracts: Comparison of intraocular pressure between normotensive and preeclamptic women in the peripartum period. Peripartum myocardial ischemia: A review of Canadian delieveries from 1970 to 1998
- Abstracts: A prospective longitudinal evaluation of pregnancy in the Marfan syndrome. Unequal placental sharing and birth weight discordance in monochronic diamniotic twins
- Abstracts: Lot-release criteria, postlicensure quality control, and the Haemophilus influenzae type b conjugate vaccines