Immunogenetic differencies between patients with familial and non-familial rheumatoid arthritis
Article Abstract:
The HLA-DR4 antigen is more common in people with hereditary rheumatoid arthritis (RA) than in people with non-hereditary RA. This was the conclusion of a study of 129 patients with hereditary RA and 217 patients with non-hereditary RA.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 2000
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Application of markers of collagen metabolism in serum and synovial fluid for assessment of disease process in patients with rheumatoid arthritis
Article Abstract:
Measurements of type I and type III procollagens (PINP, PIIINP) and the carboxylterminal telopeptide of type I collagen (ICTP) may be useful indicators for disease progression in patients with rheumatoid arthritis (RA). PINP and PIINP are molecules that form collagen, the essential protein in bone and connective tissue. ICTP is a molecule formed as collagen breaks down in bone or tissue. Researchers measured and compared levels of PINP, PIINP, and ICTP in both blood and synovial tissue of 59 patients with RA and in the blood of 90 healthy volunteers. Blood ICTP and PIIINP levels were higher than in the controls in about 50% of the patients with RA. However, these levels were lower in patients taking medication for RA as compared to those patients not taking medication. In patients with RA, blood levels of ICTP were higher than the levels of PINP. Levels of all three markers were higher in synovial fluid than in blood.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Increase of HLA-DRB1*0408 and -DQB*0301 in HLA-B27 positive reactive arthritis
Article Abstract:
There appear to be only limited genetic associations on the human leukocyte antigen (HLA)-B27 among patients with reactive arthritis. HLA helps drive the immune process. Genetic tests were run on blood samples from 63 patients with reactive arthritis, 46 with rheumatoid arthritis, and 50 healthy blood donors. Seventy-three percent of patients with reactive arthritis tested positive for HLA-B27, 38% tested positive for HLA-DRB*04, and 13% carried the closely linked genes DRB1*04-DQB1*0301. None of the other participants carried these closely linked genes.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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