Autoimmunity is triggered by cPR-3 (105-201), a protein complementary to human autoantigen proteinase-3
Article Abstract:
Immunization of mice with the middle region of cPR-3 resulted in production of antibodies not only to cPR-3 , but also to the immunogen's sense peptide counterpart, proteinase-3 (PR-3). Both human and mouse antibodies to PR-3 and cPR-3 bound to each other indicating idiotypic relatioships.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Autoimmunity: busting the atherosclerotic plaque
Article Abstract:
Autoimmunity is suspected to be a major contributor to the formation of atherosclerotic plaques. Autoimmunity might contribute to atherosclerosis with the realization that the development of the atherosclerotic plague involves both natural (innate) and adaptive immunity.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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The idiotypic network in autoimmunity: antibodies that bind antibodies that bind antibodies
Article Abstract:
A new theory about the development of autoimmunity has emerged from a surprising and miscellaneous set of observations. The elements include antibodies that recognize antibodies and a peculiar structural relationship between a sense and antisense-ecoded protein.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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