Can population differences explain the contrasting results of the Mwanza, Rakai, and Masaka HIV/sexually transmitted disease intervention trials?

Article Abstract:

A modeling study is conducted to explore whether differences between the study populations could explain the magnitude of the differences in observed trial impacts and to predict the effectiveness of each intervention strategy in leach population. The findings support the hypothesis that differences between study populations and not intervention strategy were the main determinants of the contrasting HIV impacts in Rakai, Masaka, and Mwanza.

Africa, Health aspects, Sexually transmitted diseases, Risk factors

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Mortality in HIV-infected and uninfected children of HIV-infected and uninfected mothers in rural Uganda

Article Abstract:

2-Years mortality rates in HIV-1-infected and uninfected infants born to HIV(super +) and HIV(super -) mothers are estimated. Results reveal that more than a half of HIV- infected infants died at less than 2 years of age and therefore, antiretroviral treatment (ART) might need to be initiated earlier in HIV- infected African children.

Science & research, Uganda, Research, Mortality, Patient outcomes, HIV infection, Drug therapy, HIV infections, Antiviral agents, Antiretroviral agents

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