Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Article Abstract:
The chamber and myocyte hypertrophy is suppressed on blocking the intrinsic catabolism of cGMP with an oral phosphodiesterase -5A (PDE5A) inhibitor, which also improves in vivo heart function in mice exposed to chronic pressure overload induced by transverse aortic constriction. The inhibitor reverses pre-established hypertrophy induced by pressure load while restoring chamber function to normal.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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PKC-alpha regulates cardiac contractility and propensity toward heart failure
Article Abstract:
The protein kinase C (PKC)-alpha is identified as a fundamental regulator of cardiac contractility and Ca (+2 super) handling in myocytes. Results of the study suggest PKC-alpha functions as a nodal integrator of cardiac contractility by sensing intracellular Ca (+2 super) and signal transduction events, which can profoundly affect propensity toward heart failure.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Calcium handler mishandles heart
Article Abstract:
A stress-response protein kinase C-alpha (PKC-alpha) is linked to abnormalities in calcium handling and worsening of heart failure. The inner workings of this key regulator are discussed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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