Circulating levels of the antiangiogenic marker sFLT-1 are increased in the first versus second pregnancies

Article Abstract:

A hypothesis, which suggests that nulliparous women demonstrate increased soluble fms-like tyrosine kinase (sFlt-1) levels compared with multiparous women, an overall increase in relative antiangiogenesis during first pregnancies, is tested. Significant interaction between ethnicity and pregnancy order on sFlt-1 levels is observed such that Hispanic women demonstrated greater sFlt-1 levels than white women during their first pregnancy but lower levels in their second pregnancies.

Diagnosis, Neovascularization, Angiogenesis inhibitors

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Serum sFlt1 concentration during preeclampsia and mid trimester blood pressure in healthy nulliparous women

Article Abstract:

Serum fms- like tyrosine kinase 1 (sFlt1) concentration during preeclampsia is associated with mid trimster blood pressure, other maternal characteristics, or pregnancy outcomes. It is concluded that women with higher mid trimster blood pressure has preeclampsia at lower serum sFlt1 concentrations and higher blood pressure reflect occult endoptheial damage.

Women, Women's health, Diabetes in pregnancy, Gestational diabetes

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Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia later in pregnancy

Article Abstract:

A study is conducted to determine whether circulating human leukocyte antigen G (HLA-G) levels, early in pregnancy, predict the subsequent development of preeclampsia (PE). Results indicate that HLA-G levels in plasma from women who subsequently develop preeclampsia are lower than control patients, as early as the first trimester.

HLA histocompatibility antigens, HLA antigens, Histocompatibility antigens

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