Circulating maternal corticotropin-releasing hormone and gonadotropin-releasing hormone in normal and abnormal pregnancies
Article Abstract:
The amount of circulating maternal corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GnRH) appears to vary during pregnancy. The amounts do not appear to serve as useful predictors of early miscarriage. Researchers periodically measured blood levels of CRH and GnRH in 51 women throughout pregnancy. CRH increased steadily to a peak amount during labor. GnRH increased in early pregnancy, declined in mid-pregnancy, and increased again at the end of pregnancy. Concentrations were similar in 33 women having full-term pregnancies and 10 women experiencing early miscarriage or premature delivery.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Role of nitric oxide on the central hemodynamic response to acute volume expansion in the pregnant rat
Article Abstract:
Nitric oxide may relax blood vessels during pregnancy so the woman does not suffer adversely from the high blood flow necessary to handle the metabolic requirements of both mother and fetus. Researchers gave pregnant rats an intravenous infusion of an albumin solution to mimic increased fluid in the circulatory system. Some of the rats also received a drug that inhibits nitric oxide formation. In the rats that did not receive this drug, the increased fluid caused a relaxation of blood vessels but no increase in blood pressure. This effect was not seen in the rats who received the drug.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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The acute pressure natriuresis response blunted and the blood pressure response reset in the normal pregnant rat
Article Abstract:
The normal response of the kidneys to an increase in blood pressure appears to be absent during pregnancy. Normally, an increase in blood pressure causes the kidneys to excrete more sodium, which in turn causes water to be eliminated. Pregnant women experience an increase in blood volume and pressure but retain sodium and water. A study in rats showed that increased blood pressure caused sodium and water loss in non-pregnant rats but not in pregnant rats. The change occurred in the kidneys, which became less responsive to increased blood pressure.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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