Deferral of blood donors with risk factors for HIV infection saves lives and money in Zimbabwe

Article Abstract:

A risk assessment protocol may be a useful tool for turning away potential blood donors at risk for HIV infection. A protocol called Defer/Test effectively reduced both costs and HIV contamination risks in Zimbabwe blood collection center. A risk deferral program before antibody testing of blood units would yield several advantages. Blood would be accepted only from donors not reporting any risk factors for HIV infection. This approach would eliminate people who are recently infected with HIV but would not be identified by an HIV antibody test. It also would cut the financial loss of having to throw away HIV-positive blood, even though replacement donors would have to be enlisted. Screening methods for risk factors would also circulate information about prevention.

Health aspects, Safety and security measures, Zimbabwe, Blood transfusion

---

Inhibition of HIV infection of H9 cells by chlorpromazine derivatives

Article Abstract:

Chlorpromazine may be capable of preventing HIV from infecting T cells especially when used in conjunction with zidovudine. The initial step in T cell infection occurs when the gp120 viral protein binds to the CD4 T cell receptor. This involves an electrostatic attachment that could be blocked by charged molecules such as chlorpromazine. Researchers studied several derivatives of chlorpromazine and found that 7,8-dioxo-chlorpromazine blocked the attachment of recombinant gp120 and also prevented infection of a T cell culture in the presence of zidovudine.

Infection, Physiological aspects, T cells, Chlorpromazine

---

CCR5del32 in perinatal HIV-1 infection

Article Abstract:

This concerns research into a chemokine receptor known as CCR5, which, when altered by deletion of 32-bp from the genetic code (del32), seems able to prevent HIV-1 from infecting T-cells. This simulates a natural allele present in a small portion of Caucasian people.

Statistical Data Included, Cytokines, Varieties

Similar abstracts:

• Abstracts: Prevalence of and risk factors for lifetime suicide attempts among Blacks in the United States. Violence-related behaviors among high school students-United States, 1991-2003
• Abstracts: Prevalence, incidence, and risks for HIV-1 infection in female sex workers in Miami, Florida. HIV prevalence and sexual behavior in a cohort of New York City gay men (aged 18-24)
• Abstracts: Consumer protections for people living with HIV within systems of managed care
• Abstracts: A disease in motion: diabetes history and the new paradigm of transmuted disease. The day after: how insulin was received by the medical profession
• Abstracts: Enabling patients to make informed decisions. Assessing the capacity to give consent. Organ procurement: pitfalls and pathways

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.