Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
Article Abstract:
The protein p27(super Kip1) progressively accumulates in the nucleus of pancreatic beta cells in mice that like either insulin receptor substrate 2 or the long form of the leptin receptor. Deletion of the gene encoding p27(super Kip27) ameliorated hyperglycemia in these animal models of type 2 diabetes mellitus by increasing islet mass and maintaining compensatory hyperinsulinemia effects.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation
Article Abstract:
NF-kappaB appears to be essential for normal liver function. When its activity was blocked in mice, they were unable to clear a Listeria infection from the liver. NF-kappaB inhibition has been proposed as a therapeutic agent.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Pancreatic and duodenal homeobox gene 1 induces experssion of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
Article Abstract:
The pancreatic and duodenal homeobox gene 1 (PDX-1) can re-program non-pancreatic tissues to produce insulin. This was done in mice, whose livers began producing functional insulin after gene transfer of PDX-1.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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