Mouse monoclonal antibodies directed against the HTLV-I protease recognize epitopes internal to the dimer
Article Abstract:
Monoclonal antibodies against specific parts of the protease of the human T-cell leukemia virus type I (HTLV-I) could prevent replication of the virus. The protease consists of two proteins that join to form a dimer. The dimer contains the active site of the enzyme, and the enzyme is essential for viral replication. Researchers created three mouse monoclonal antibodies that bound to various portions of the protein. Several of the sites are important in stabilizing the enzyme. Consequently, the antibodies could disrupt the formation of the dimer and block enzyme activity.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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Inflammatory polyarthropathy and bone remodeling in HTLV-I Tax-transgenic mice
Article Abstract:
The tax protein of human T-cell lymphotropic virus type I (HTLV-I) may produce the arthritis that sometimes occurs in people infected with this virus. Researchers studied mice that had been bred to contain the gene that produces the tax protein. Some of these mice developed arthritis in their knees, ankle and toes whereas normal mice did not. By 20 months of age, 43% of the mice had arthritis. The extent of joint damage revealed by X-rays was related to the number of tax genes present in the total genome.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
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