Stimulation of the CD2 receptor pathway induces apoptosis in human T lymphotropic virus type I-infected cell lines
Article Abstract:
Cells infected with human T lymphotropic virus type I (HTLV-I) appear to undergo programmed cell death, or apoptosis, upon stimulation of the CD2 receptor. The CD2 receptor is thought to have a role in the abnormal immune regulation that is a characteristic of HTLV-I infection. Researchers used antibodies against CD2 receptors to activate them in cell lines that were infected with HTLV-I. Cell proliferation was shown to decrease by 25% to 62% with antibody treatment. After 3 days, 35% of antibody-treated cells had died. Cell counts after antibody treatment were 40% below normal after 3 days. The antibody-treated cell lines showed the characteristic signs of programmed cell death. Activation of the CD3 receptor in these cell lines did not result in cell death. Cyclosporin A could only interfere with CD2-mediated activity in cell lines that were not infected with HTLV-I. As HTLV-I itself activates the CD2 receptor, the findings indicate that HTLV-I-infected cells are primed to undergo cell death upon additional activation of the CD2 receptor.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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HTLV-I and HTLV-II virus expression increase with HIV-1 coinfection
Article Abstract:
HIV infection may influence the activity of human T-cell lymphotropic virus (HTLV) in patients infected with both viruses. Researchers analyzed 24 patients infected with both HIV and HTLV-I or HTLV-II, and 13 patients infected with HTLV-I/II alone. Patients with dual infection had more HTLV-I/II antigen expression in white blood cells, and 58% showed genetic evidence of viral regulation, cellular transformation, and other indications of HTLV-I/II disease processes. Only 7% of HIV-negative patients with HTLV-I/II infection showed such evidence of HTLV genetic activity.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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Cell adhesion molecules in HTLV-I infection
Article Abstract:
Various cell adhesion molecules exist on T cells infected with the human T-cell lymphotropic virus type I (HTLV-I). This was demonstrated in samples of leukemic cells from 10 patients with adult T-cell leukemia, which is caused by HTLV-I. The cells contained the adhesion molecules E-selectin as well as L-selectin, LFA-1, VLA-1 and CD44. They also contained an undescribed adhesion molecule. These molecules allow the leukemic cells to infiltrate organs such as skin, liver, spleen and lungs.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
User Contributions:
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