Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men

Article Abstract:

Men with hypertension who are treated with thiazide may not have higher risk of developing severe potassium deficiency or ventricular arrhythmia (irregular heartbeat) than those who are not treated with thiazide. Out of 212 men between 35 and 70 years old with high blood pressure, 60 were treated with thiazide, 29 were treated with thiazide plus potassium, 34 were treated with thiazide plus potassium and magnesium, 29 were treated with thiazide plus triamterene, 30 were treated with the anti-hypertension drug chlorthalidone, and 27 were treated with a placebo, an inactive substance. Those treated with thiazide or chlorthalidone had a larger decrease in blood potassium, but they did not have a higher occurrence of ventricular arrhythmia than men who received a placebo. Men who received thiazide with the potassium, potassium and magnesium or triamterene supplement did not have higher blood potassium levels than those treated with thiazide alone. Twelve men in the thiazide alone and chlorthalidone groups had severe deficiency of blood potassium, and the occurrence of ventricular arrhythmia was twice as high among these men.

Complications and side effects, Thiazides

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Prevalence and correlates of herpes simplex infections: the population-based AIDS in Multiethnic Neighborhoods Study (AMEN Study)

Article Abstract:

Herpes simplex infections may be increasing in the US, especially in individuals who behave in ways that place them at risk for viral infections. Researchers interviewed 1,770 individuals in three San Francisco, CA neighborhoods and also took a blood sample that was later tested for antibodies to herpes simplex virus 1 (HSV-1) and 2 (HSV-2). Two-thirds of the individuals were infected with HSV-1 and one-third were infected with HSV-2. Hispanics were more likely to be infected, as were men and women who had many sexual partners and those who used intravenous drugs, crack cocaine or alcohol. The neighborhoods canvassed had high rates of sexually transmitted diseases and admissions to drug detoxification programs. These individuals may be at risk of herpes simplex infections, which could increase their risk of infection with HIV, the virus that causes AIDS.

Measurement, Demographic aspects, Diseases, Ethnic groups, Herpes simplex virus, Herpes simplex

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Trends in antihypertensive drug use in the United States: do the JNC V recommendations affect prescribing?

Article Abstract:

The recommendations of the Fifth Joint National Committee on the Detection, Evaluation, and Treatment of High Blood Pressure (JNC V) in 1993 appear to have had minimal impact on 1995 prescribing patterns. The Committee recommended hydrochlorothiazide, a diuretic, and beta-blockers as initial treatment for most patients. A review of all antihypertensive prescriptions at approximately 35,000 pharmacies in 1992 and 1995 showed that use of calcium antagonists and ACE inhibitors increased, while diuretic and beta-blocker use decreased, a pattern contrary to the recommendations.

Health aspects, Drugs, Prescriptions (Drugs), Antihypertensive drugs, Antihypertensive agents

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