Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
Article Abstract:
A demonstration that a new class of antibiotics, acyldepsipeptides, has antibacterial activity against Gram-positive bacteria in vitro and in several rodent models of bacterial infection is presented. It is shown that the acyldepsipeptides are active against isolates that are resistant to antibiotics in clinical application, implying a new target, which is identified as ClpP, the core unit of a major bacterial protease complex.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Antibacterial discovery and development-the failure of success?
Article Abstract:
The path taken over six decades of antibacterial research and development is traced.The industry trends that emerged at different times to combat new challenges and relevant lessons from antibacterial compound discovery and the relevant lessons for present-day antibacterial compound discovery, current approaches to combat resistance, and problems with regulatory oversight and commercial development issues are discussed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Drugs for bad bugs: Confronting the challenges of antibacterial discovery
Article Abstract:
A study was conducted with the objective of finding a novel antibacterial compound that had either Gram-positive or broad-spectrum activity. The findings reveal that synthesizing novel chemical structures that interact with and block established targets in new ways is a robust strategy.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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