Effect of a retroviral immunodeficiency syndrome on resistance to MCMV: a role for natural killer cells
Article Abstract:
Cytomegalovirus may develop more rapidly in AIDS patients because AIDS delays the immune response. Cytomegalovirus is the leading viral cause of death among AIDS patients. Researchers investigated the effect of cytomegalovirus infection on mice which had been infected with AIDS. The AIDS infection weakened the T cell immune response and affected the lymph glands of the mice. Although the mouse immune system was able to rid the spleen, liver, and salivary glands of cytomegalovirus a few days after these organs were infected by researchers, the amount of cytomegalovirus was greater in mice with AIDS than in mice without AIDS. The natural killer immune response and production of interferon was delayed and was less effective in mice with AIDS.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Multiple superinfections fail to activate defective human immunodeficiency virus-1 (HIV-1) infection of rabbits
Article Abstract:
Using rabbits as a model for studying HIV type 1 disease may not provide information applicable to most humans with the disease but it may illustrate resistance to AIDS after HIV infection in some humans. Researchers infected five groups of rabbits with HIV-1 disease and one other infectious or viral disease per group to see if the other diseases could stimulate progression of HIV disease, as has been noted in humans. The rabbits' HIV disease did not progress, their immune systems were able to fight the other diseases, and they stayed healthy for up to four years after being infected with HIV. No HIV DNA was found in their blood cells.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Biological significance of human endogenous retroviral sequences
Article Abstract:
There is much research needed on the possible biological effects of human endogenous retroviruses (HERV). HERV are gene sequences similar to exogenous retroviruses that make up 1% of the human genome. In many cases, they contain the full complement of viral genes, but most cannot replicate. However, they still produce proteins that could activate an autoimmune response. They could produce proteins that act as superantigens, depleting entire classes of T cells. They could also transpose into or near a cellular gene, rendering it inactive.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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