Effect of highly active antiretroviral therapy on the natural history of anal squamous intraepithelial lesions and anal human papillomavirus infection
Article Abstract:
The effect of highly active antiretroviral therapy (HAART) on the natural history of anal squamous intraepithelial lesions (ASIL) - the likely anal cancer precursor - and anal human papillomavirus (HPV) infection has been studied. Results show that HAART has only a small effect on ASIL or HPV in the first 6 months after HAART is started. The men who had sex with men (MSM) in the study had been followed in a cohort study for several years before HAART became available so it was possible to compare the natural history before and after HAART initiation. AIDS is a risk factor for anal HPV infection and ASILs in men.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors
Article Abstract:
HIV-positive homosexual men may be at higher risk than HIV-negative men of developing cellular changes in the anus that could lead to anal cancer. Researchers examined 346 HIV-positive and 262 HIV-negative homosexual and bisexual men for evidence of anal squamous intraepithelial lesions (ASIL). ASIL was detected in 36% of men with HIV and 7% of men without HIV infection. Anal infection with human papillomavirus and a history of receptive anal intercourse increased the risk of ASIL, regardless of HIV status. Screening of homosexual men for ASIL may prevent anal cancer.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men
Article Abstract:
HIV-positive homosexual men may be at higher risk for anal squamous intraepithelial lesions (ASIL) and possibly for anal cancer than HIV-negative homosexual men. ASIL are cellular changes that may develop into cancer. Researchers examined 346 HIV-positive and 262 HIV-negative homosexual men for evidence of anal diseases. Twenty percent of HIV-positive men developed high-grade intraepithelial lesions, compared to 8% of HIV-negative men, during the two years they were studied. Infection with human papillomavirus increased the risk of ASIL, regardless of HIV status.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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