Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

Article Abstract:

Research has shown that cardiac fibrosis is associated with the emergence of fibroblasts originating from endothelial cells, which has indicated an endothelial-mesenchymal transition (EndMT) similar to events that occur during formation of the atrioventricular cushion in the embryonic heart. The results have shown that EndMT has contributed to the progression of cardiac fibrosis and that rhBMP-7 can be used for inhibiting EndMT and for intervening in the progression of chronic heart disease associated with fibrosis.

Causes of, Risk factors, Heart diseases, Fibroblasts, Fibrosis, Clinical report

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Chipping away at gallstones

Article Abstract:

The mechanics of farnesoid x receptor (FXR), a transcription factor that regulates the composition of bile, the digestive fluid produced in the liver is examined. This new research could lead to effective noninvasive treatments for patients with symptomatic gallstones.

United States, Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Medical Research, Epilepsy & Muscle Disease R&D, Administration of Public Health Programs, Health Research Programs, Care and treatment, Gallstones, Bile, Medicine, Experimental

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