Essential role of stromally induced hedgehog signaling in B-cell malignancies
Article Abstract:
Hedgehog ligands secreted by bone-marrow, nodal and splenic stromal cells have functioned as survival factors for malignant lymphoma and plasmacytoma cells derived from transgenic [E.sub.[mu]]-Myc mice or isolated from humans with these malignancies. The results have shown that stromally induced hedgehog signaling might provide a vital survival signal for B- and plasma-cell malignancies in vitro and in vivo.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Marrow to muscle, fission versus fusion
Article Abstract:
Participation of bone marrow cells in muscle regeneration results from the 'bona fide' generation of myogenic progenitors, or by fusion with the newly formed myotubes. Results from the experiments of Corbel et al. and Camargo et al. are used to deal with the issue.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Skeletal remodeling in health and disease
Article Abstract:
The article presents the causes of bone cells to become dysfunctional and the options available for control and treatment.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Fruits of molecular studies include gene linking diet and cancer, novel markers for malignancy. Low-carb, low-fat diet gurus face off
- Abstracts: The many faces of celiac disease. The prevalence of occult gastrointestinal bleeding in celiac sprue. Celiac disease -- the villain unmasked?
- Abstracts: Determinants of vaginal-perinatal integrity and pelvic floor functioning in childbirth. Intimate partner violence and adverse pregnancy outcomes: a population-based study
- Abstracts: T cells bite the hand that feeds them. Embedding T cells in the matrix. Fatal attraction: Tumors beckon regulatory T cells
- Abstracts: Vasopressin: friend or foe? Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses