Evaluation of a deoxyribonucleic acid probe for the detection of Trichomonas vaginalis in vaginal secretions

Article Abstract:

Trichomoniasis may be accurately detected with the use of a nonculture test which may be used outside of laboratory settings. Trichomoniasis is a common sexually transmitted disease. Researchers collected vaginal samples from 615 women suspected of having trichomoniasis and analyzed them with a new DNA probe test known as Affirm VP, with microscopic examination of wet preparations, and with culture in modified Diamond's medium. Cultures in Diamond's medium identified most (98%) of the 95 cases of trichomoniasis, Affirm VP identified 86 cases (90.5%), and examination of wet preparations identified 76 cases (80%). The detection rate of Affirm VP may be acceptable and allow for processing of multiple samples at a time, with results available in one hour.

Evaluation, Diagnosis, DNA probes, Trichomoniasis

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First antenatal visits and metronidazole

Article Abstract:

Women in early pregnancy may be treated for bacterial vaginal infections without causing undue harm to the fetus. Researchers analyzed the estimated weeks of pregnancy at women's initial prenatal visits to five obstetric practices. Most women were seen for their initial prenatal visit after nine completed weeks of pregnancy, by which time much of the fetus's organ development is completed. Women who are nine weeks' pregnant or more who are treated with oral metronidazole for vaginal infections may not experience fetal complications. However, the best time to treat vaginal infections is before conception.

Health aspects, Risk factors, Drug therapy, Pregnant women, Vaginosis, Metronidazole, Teratogenesis

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Diurnal variation in saliva estriol level during pregnancy:a pilot study

Article Abstract:

Doctors who measure estriol in a pregnant woman's saliva to determine whether she will deliver prematurely should do so during the day. Estriol is produced by the fetus and crosses the placenta into the mother's blood, urine and saliva. Estriol levels rise as delivery approaches. Researchers measured estriol in saliva samples that 14 pregnant women collected at various times during the day and night. Estiol levels began to increase at 10 p.m., reaching a peak at 4 a.m., and returning to day levels by 7 a.m. The levels did not vary substantially during the day.

Measurement, Circadian rhythms, Pregnancy, Estrogen, Estrogens

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