In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein
Article Abstract:
Research demonstrates that hematopoietic stem cells exposed to recombinat TAT-human homeobox B4 for 4 days expands stem cells by about four- to six-fold abd 8-20 times the control cultures. Data indicate that these stem cells normally differentiate and repopulate.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Canada, Physiological aspects, Growth, Cell differentiation, Hematopoietic stem cells, Recombinant proteins, Cell culture, Tissue culture, Company growth
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
Article Abstract:
In vitro studies suggest that AML-1 has a pivotal role in adult hematopoiesis. AML-1 is thus required for maturation of megakaryocytes and differentiation of T and B cells, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
United States, Science & research, Research, Hematopoiesis, Acute myelocytic leukemia
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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