Examining the molecular genetics of HTLV-I with an infectious molecular clone of the virus and permissive cell culture systems
Article Abstract:
Several cell culture techniques are described that would allow the genetic characterization of the HTLV-I virus. HTLV-I was first discovered in 1980 and has been linked to adult T-cell leukemia, tropical spastic paraparesis and HTLV-associated myelopathy. However, the virus is very difficult to grow in culture. A mammalian cell line was infected with a clone of an HTLV provirus and the culture produced viral nucleic acids and proteins. These virus particles were able to infect a T cell culture. A fetal rhesus monkey lung cell line has been established that can support the production of HTLV clones.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Maternal vitamin A deficiency and child growth failure during human immunodeficiency virus infection
Article Abstract:
Vitamin A deficiency during pregnancy could affect the growth of the baby. Researchers followed 467 HIV-infected women and examined their children every 3 months until the age of two. By the age of one, babies of mothers who had a vitamin A deficiency during pregnancy were about 0.7 kilograms lighter and about 1 centimeter shorter compared to babies of mothers with normal vitamin A levels. Vitamin A is converted in the body to retinol, which regulates the production of growth hormone.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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Blood collection on filter paper: a practical approach to sample collection for studies of perinatal HIV transmission
Article Abstract:
Blood spots collected on filter paper may offer an inexpensive way to test people in developing countries for HIV infection. A study of 15,810 blood samples collected in this manner from pregnant women in south Africa found that the polymerase chain reaction could be used on the samples with an accuracy of 98% to 100% depending on whether a second test was done. Transport and shipping of the samples was much easier than normal blood samples and did not require refrigeration.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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