Fibrodysplasia ossificans progressiva - lessons from rare maladies

Article Abstract:

Research on the causes of abnormal bone formation in people with fibrodysplasia ossificans progressiva may also explain why healthy people often form abnormal bone deposits. Fibrodysplasia ossificans progressiva is a genetic disorder that leads to abnormal bone formation in soft tissue. The formation of bone in soft tissue can also occur in healthy people who suffer trauma or have a hip replaced. A 1996 study found that the levels of bone morphogenetic protein 4 were elevated in blood cells from patients with fibrodysplasia ossificans progressiva but not in a group of healthy people.

Editorial

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Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva

Article Abstract:

An overexpression of bone morphogenetic protein 4 appears to be responsible for the abnormal bone formation that characterizes fibrodysplasia ossificans progressiva. This genetic disorder results in widespread bone formation that can literally cripple the body. These proteins are normally only produced when a bone is fractured. Researchers found increased levels of bone morphogenetic protein 4 in 26 out of 32 white blood cell samples taken from patients with this disease. Only 1 out of 12 samples from healthy volunteers contained elevated levels of the protein.

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First-trimester placentation and the risk of antepartum stillbirth

Article Abstract:

The study aimed to determine whether the risk of antepartum stillbirth varies in relation to circulating markers of placental function measured during the first trimester of pregnancy is discussed. It is concluded that the risk of stillbirth in late pregnancy may be determined by placental function in the first ten weeks after conception.

Risk factors, Abruptio placentae, Placental abruption, Prenatal diagnosis, Still-birth, Stillbirth

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