Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
Article Abstract:
A class of secreted staphylococcal peptides with the ability to recruit, activate and subsequently lyse human neutrophils, eliminating main cellular defense against Staphylococcus aureus infection is discussed. The peptides are produced by standard community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains contributing to the strains' ability to cause disease in animal models of infection.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury
Article Abstract:
2-(phosphonomethyl)pentanedioic acid (2-PMPA) appears to prevent ischemic brain injury during stroke by inhibiting NAALADase. This enzyme hydrolyzes N-acetyl-aspartyl-glutamate (NAAG), which in turn produces the excitatory amino acid glutamate. Excessive glutamate levels can be toxic to the brain.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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