Immunity to reinfection and immunization of male guinea pigs against urethral infection with the agent of guinea pig inclusion conjunctivitis
Article Abstract:
Men who have recovered from genital infection with chlamydia may be more resistant to reinfection than women. An injection of inactivated chlamydia into the male urethra may become a vaccine against chlamydial genital infection. Researchers studied male and female guinea pigs to determine if immunity to subsequent chlamydial infection occurs after recovery from an infection. Male guinea pigs showed resistance to reinfection for up to 150 days after the first infection, while female guinea pigs resisted infection only for 30 days after the initial infection. Length of infection was similar for males and females. Immunization with inactivated chlamydiae prevented severe genital infections in both male and female animals. Immunization by injection or by the oral route may become a vaccine against chlamydia infection.
Publication Name: Sexually Transmitted Diseases
Subject: Health
ISSN: 0148-5717
Year: 1996
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Increased incidence of oviduct pathology in the guinea pig after repeat vaginal inoculation with the chlamydial agent of guinea pig inclusion conjunctivitis
Article Abstract:
Repeated chlamydia infection appears to increase the risk of fallopian tube damage in guinea pigs. Guinea pigs were infected vaginally with chlamydia. Some of the animals were reinfected at 73 or 77 days after the primary infection. All animals were subsequently killed and their fallopian tubes examined microscopically. Blood serum was collected to test for antibodies. Thirty days after reinfection, 56% of the guinea pigs had pathological changes associated with infertility in their fallopian tubes compared with only 23.5% of those who only had one infection. Although it is theorized that fallopian tube damage results from an inflammatory reaction to infection, antibody test results did not correlate with the presence of tubal dilation.
Publication Name: Sexually Transmitted Diseases
Subject: Health
ISSN: 0148-5717
Year: 1995
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Effects of nonoxynol-9 on vaginal microflora and chlamydial infection in a monkey model
Article Abstract:
One dose of vaginal nonoxynol-9 appears to reduce the risk of Chlamydia infection. Nonoxynol-9 kills sperm and is used in contraceptive preparations inserted vaginally. However, it also kills infective organisms. Researchers determined the preventative effect of a single vaginal application of nonoxynol-9 in monkeys exposed to Chlamydia. Nonoxynol-9 prevented infection in 4 out of 6 monkeys. Vaginal irritation was minor and only short-term effects on the normal vaginal bacterial population were seen. The consequences of multiple applications are unknown.
Publication Name: Sexually Transmitted Diseases
Subject: Health
ISSN: 0148-5717
Year: 1996
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