High-density lipoprotein cholesterol and other risk factors for coronary heart disease in female runners

Article Abstract:

Women might benefit from exercise that exceeds the 1995 recommendations proposed by the Centers for Disease Control and Prevention. At that time, the CDC reported that Americans could gain the majority of health benefits by walking briskly for two miles every day. Researchers analyzed the medical records of 1,837 female runners and solicited information about how far they ran each week. Blood levels of high-density lipoprotein (HDL) cholesterol, which protects against heart disease, increased substantially the farther the women ran each week. Women who ran the longest distances had HDL cholesterol levels 10 milligrams per deciliter (mg/dl) higher than women who ran the shortest distances. Many of the women who ran 40 miles a week or more had HDL levels of 80, 90 or 100 mg/dl. This could reduce their risk of coronary heart disease by 29% and their mortality rates by 45%. However, 24% of the women no longer had menstrual periods.

Measurement, Physiological aspects, Running, Cholesterol, HDL, HDL cholesterol lipoproteins, Women athletes

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Getting a handle on "good" cholesterol with the high-density lipoprotein receptor

Article Abstract:

Research continues to elucidate the role of the receptor for high-density lipoproteins (HDL). HDL remove cholesterol from the blood and tissues and deliver it to the liver. In 1996, the receptor for HDL was discovered. It is called scavenger receptor, class B, type I (SR-BI). It occurs in the liver, ovaries, adrenal glands, and testes. In mouse studies, an increase in SR-BI lowers HDL cholesterol levels and eliminating the receptor raises them. Increasing SR-BI inhibits atherosclerosis whereas eliminating it promotes atherosclerosis.

Research, High density lipoproteins, Cell receptors, High density lipoprotein receptors

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