Interleukin-1beta and interleukin-4 increase parathyroid hormone-related protein secretion by human umbilical vein endothelial cells in culture
Article Abstract:
Interleukin-1beta (IL-1beta) and interleukin-4 (IL-4) appear to play a role in regulating the secretion of parathyroid hormone (PTH)-related protein secretion. PTH-related protein is secreted by a wide variety of cells, including cells in the uterus, placenta, fetal membranes, and the cells lining umbilical cord veins. It can relax uterine muscle and the muscle of blood vessel walls. Researchers measured the effect of various substances on PTH-related protein secretion in a culture of cells from the lining of human umbilical cord veins. Of the compounds tested, only IL-1beta and IL-4 caused the cultured cells to increase secretion of PTH-related protein. Incubation with inhibitors of IL-1beta along with IL-1beta reduced the secretion of PTH-related protein.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acid in human amnion and chorion-decidua: implications for secretion and function
Article Abstract:
The placental membranes of human fetuses may contain a system of locally released and locally acting parathyroid hormone (PTH)-related peptides. Researchers used light and electron microscopy to analyze fetal membranes from recently delivered placentas, from both laboring and non-laboring women. PTH-related peptide was found throughout the placental membranes, and the peptide receptor mRNA was found in the outermost membranes. PTH-related peptide was found in the lining of the amniotic sac, amniotic fluid, and in the outermost membranes and uterus. PTH-related peptide may be produced by the innermost membranes, and may act upon certain cells in the outermost membranes. The PTH-related peptide receptor has not been identified in human placenta before.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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Expression and specific immunolocalization of the human parathyroid hormone/parathyroid hormone-related protein receptor in the uteroplacental unit
Article Abstract:
The placenta, the uterus and the umbilical cord all contain the receptor for parathyroid hormone-related protein. This protein produces some of the same effects as parathyroid hormone. Researchers tested tissue samples of the placenta, uterus and umbilical cord for the presence of the receptor and found it in uterine smooth muscle, and in the blood vessels supplying the uterus. It was also found in the blood vessels in the umbilical cord. The protein may play a role in the relaxation of the uterus and its blood vessels.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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