Intravenous immunoglobulin therapy for the antiphospholipid syndrome in pregnancy

Article Abstract:

Intravenous immunoglobulin therapy may improve pregnancy outcomes among women with antiphospholipid syndrome. This autoimmune reaction associates with lupus erythematosus. It causes clotting disorders that lead to pregnancy loss. Anticlotting therapies may have some beneficial effect but do not prevent all losses. Five women with 17 prior pregnancy losses and no surviving children received intravenous immunoglobulin therapy for five days every month beginning in the first or early second trimester. Four women also received heparin and four women aspirin as anticoagulant therapy. Three women showed decreases in blood levels of anticardiolipin immunoglobulin G. Four women had healthy term infants; the fifth underwent a cesarean at 32 weeks gestation for fetal distress. The 5-minute Apgar was 8. There were no cases of preeclampsia, fetal growth retardation, or maternal deep venous clots.

Drug therapy, Antiphospholipid syndrome, Pregnancy, Complications of, Pregnancy complications

---

Clinical uses of intravenous immunoglobulin in pregnancy

Article Abstract:

Intravenous immunoglobulin therapy may be useful for various obstetric complications. The FDA has labelled intravenous immunoglobulin for just a few uses, but the obstetric literature reports more uses for the therapy during pregnancy. IV immunoglobulin was approved for use in the US in 1981. The therapy may be used during pregnancy to treat autoimmune thrombocytopenic purpura, to avoid long-term use of steroids, and in the early second trimester for fetuses diagnosed with neonatal alloimmune thrombocytopenia. It may be used in individual cases for recurrent pregnancy loss, thromboembolism, and antiphospholipid thrombocytopenia.

Pregnancy

---

Maintenance oral nifedipine for preterm labor: a randomized clinical trial

Article Abstract:

The calcium channel blocker nifedipine appears to be ineffective in prolonging labor in pregnant women in premature labor. Premature babies have many health problems and the number of premature births has increased since the 1950s.

Evaluation, Prevention, Premature labor, Nifedipine

Similar abstracts:

• Abstracts: Transport of immunoglobulin G and its subclasses across the in vitro-perfused human placenta
• Abstracts: Surgical versus nonsurgical therapy for lumbar spinal stenosis. Surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis
• Abstracts: Immunity to reinfection and immunization of male guinea pigs against urethral infection with the agent of guinea pig inclusion conjunctivitis
• Abstracts: Direct immunofluorescence vs. culture for detecting HSV in oral ulcers: a comparison. Prophylaxis with nystatin pastilles for HIV-associated oral candidiasis
• Abstracts: Can plans manage the preventive care diabetics need? Medicaid misgivings. HMOs fear pay trouble under Ill. Medicaid managed care

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.