Direct immunofluorescence vs. culture for detecting HSV in oral ulcers: a comparison

Article Abstract:

Viral culture tests appear to be more accurate than direct immunofluorescence in detecting herpes simplex virus (HSV) in mouth and tongue sores. The drawback to viral culture tests is that they take several days. Direct immunofluorescence takes only a few hours. A group of 51 men was subjected to both diagnostic tests. Forty-nine of the patients were HIV-positive. The direct immunofluorescence technique was fast but failed to detect all HSV cases compared with the culture test. The cell count was too low in 12% of the cases to reliably determine the presence or absence of HSV. For the general dentist who treats outpatients and not many HSV cases, the standard viral culture method seems to be the method of choice.

Diagnosis, Cultures (Biology), Immunofluorescence, Fluorescent antibody technique, Herpesvirus diseases, Herpesvirus infections

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Prophylaxis with nystatin pastilles for HIV-associated oral candidiasis

Article Abstract:

Nystatin lozenges can effectively delay the onset of oral candidiasis in HIV patients. Oral candidiasis, the most prevalent infection in HIV patients, is a painful condition caused by the Candida albicans (C. albicans) organism. Nystatin, the antifungal antibiotic, delayed the time to oral candidiasis in 128 randomized HIV-infected male subjects. Most likely to benefit from Nystatin treatment include HIV patients with CD4 counts over 200 who have C. albicans infections and those who have had previous oral candidiasis.

Prevention, Physiological aspects, Nystatin

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Effect of cigarette smoking on HIV-related oral lesions

Article Abstract:

Smoking may increase the risk of oral lesions in HIV-infected people. Researchers examined 693 HIV-infected men for oral lesions such as oral candidiasis, hairy leukoplakia, and aphthous ulceration. These lesions are common in HIV-infected patients. Almost half the men had one lesion and 31% had one or more different types. Smokers were about twice as likely to have candidiasis or hairy leukoplakia compared to non-smokers. However, they were much less likely to have aphthous ulcers.

Health aspects, Risk factors, Smoking, Leukoplakia, Oral, Oral leukoplakia

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