Lupus "gatekeeper" gene discovered
Article Abstract:
Findings reveal that the restoration of the levels of receptors coded by a single 'gatekeeper' gene could halt the development of lupus in mice. An inhibitory Fc receptor that plays a critical role in the ability of the immune system to distinguish between self and nonself in the mouse was identified, and found that even partial restoration of the receptor's function prevented the development of lupus in several lupus-prone mouse strains.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
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Scientists seek cause of drug craving
Article Abstract:
Repeated administration of psychoactive drugs such as cocaine and amphetamine and corresponding reduction in glutamate mediated communication between glutamate receptors and cell signaling in the nucleus accumbens play a role in drug-craving. A study on a rat model suggested that a reduced number of glutamate receptors in the nucleus accumbens caused by repeated drug exposure account for drug-craving behavior.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
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Nobels honor research on ulcer microbe, "Green" drug production method
Article Abstract:
The 2005 Nobel Prize in Physiology or Medicine is awarded to a pair of Australian researchers, Barry J. Marshall, MBBS and J. Robin Warren, MBBS, whose work revolutionized how peptic ulcers are treated. The 2005 Nobel Prize in Chemistry went to trio of chemists who developed a technique for manufacturing pharmaceuticals, plastics and other products that produces less waste.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
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