Matrix metalloproteinase activity in equine synovial fluid: influence of age, osteoarthritis, and osteochondrosis
Article Abstract:
Matrix metalloproteinase (MMP) activity appears to be greater in the synovial fluid of joints in young horses and horses with osteoarthritis (OA), compared to adult horses. MMPs are enzymes associated with cartilage growth and remodeling in joints. Researchers compared MMP levels in joint fluid samples from juvenile and adult horses and horses with OA or osteochondrosis. In healthy horses, MMP activity declined with age, indicating declining cartilage growth with age. In horses with OA, MMP activity was elevated, consistent with the cartilage destruction in this inflammatory condition. Osteochondrosis was not associated with increased MMP activity.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1998
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Influence of development and joint pathology on stromelysin enzyme activity in equine synovial fluid
Article Abstract:
The enzyme stromelysin is more active in joints affected by osteoarthritis, indicating that this increased activity may cause osteoarthritis. Stromelysin belongs to a class of enzymes called matrix metalloproteinases, which participate in the remodeling of connective tissue.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 2000
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Urokinase-mediated fibrinolysis in the synovial fluid of rheumatoid arthritis patients may be affected by the inactivation of single chain urokinase type plasminogen activator by thrombin
Article Abstract:
The hormone thrombin may prevent the breakdown of blood clots in the joints of patients with rheumatoid arthritis. It does this by inhibiting another hormone called urokinase that breaks down blood clots.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 2000
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