Mechanisms of actions of inhaled anesthetics

Article Abstract:

The actions of inhaled anesthetics on the brain and spinal cord are reviewed, focusing on nitrous oxide, halothane, enflurane, isoflurane, sevoflurane, and desflurane. Topics include lipid theories of anesthetic action, behavioral pharmacology, actions on different regions of the nervous system, molecular actions on proteins, ion channels, and gaba receptors, synaptic mechanisms, and neural networks. A glossary of terms is included.

Anesthetic Preparations, Inhaled medication, Anesthetics

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Thiazolidinediones

Article Abstract:

The understanding of the mechanisms of action of thiazolidinediones is described and a focus is made on their use as hypoglycemic therapies in patients with type 2 diabetes. Though thiazolidinediones, a new group of drugs, decrease hepatic fat content and increase insulin sensitivity in muscle, they have nonglycemic effects on the body weight, lipids, and blood pressure.

Antidiabetic Preparations, Hypoglycemic agents, Dosage and administration, Thiazolidinediones

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Putting the brakes on cylindromatosis?

Article Abstract:

Aspirin applied directly to the skin may be an effective treatment for a skin disease called familial cylindromatosis. In this condition, large benign skin tumors form, usually on the head and neck. Research has shown that these patients have a mutation in a tumor suppressor gene called CYLD. However, aspirin can overcome this defect.

Aspirin, Aspirin Combinations, Drug therapy, Skin tumors, Skin tumours

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