Microsatellite instability

Article Abstract:

Doctors should take a biopsy sample from all patients with colorectal cancer and test it for a genetic abnormality called microsatellite instability. If the patient has this abnormality, he or she probably will not benefit from fluorouracil chemotherapy after surgery. In fact, they may have a fairly good prognosis even without chemotherapy. Microsatellite instability could also be used as a screening test for hereditary colorectal cancer.

Chromosome abnormalities

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Screening for the lynch syndrome (hereditary nonpolyposis colorectal cancer)

Article Abstract:

The frequency of germ-line mutations in patients with colorectal cancer is assessed and the strategies for molecular screening to identify patients with the syndrome are examined. The results revealed that the effectiveness of screening with immunohistochemical analysis of the mismatch-repair proteins would be similar to that of the more complex strategy of genotyping for microsatellite instability.

United Kingdom, Gene mutations, Gene mutation, Cancer, Cancer screening

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Effector memory T cells, early metastasis, and survival in colorectal cancer

Article Abstract:

A study of pathological signs of early metastatic invasion in 959 specimens of resected colorectal cancer is presented. Results reveal that signs of an immune response within colorectal cancers are associated with the absence of pathological evidence of early metastatic invasion and with prolonged survival.

Care and treatment, Metastasis, Cancer metastasis, T cells

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