Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

Article Abstract:

A previously unknown T-cell co-stimulatory pathway has been identified. This research offers a new way to treat tumor necrosis factor.

T cell antigen receptors, Immune system

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Steering anti-cancer drugs away from the TRAIL

Article Abstract:

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may be too toxic to the liver to be used as a chemotherapy drug. TRAIL was believed to induce apoptosis only in cancer cells, but researchers found it can kill normal human hepatocytes also.

Causes of, Liver, Cell death, Antineoplastic agents

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B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

Article Abstract:

Researchers have identified a third B7 protein called B7-H1 that stimulates the production of interleukin-10. This would inhibit the cellular immune response. The B7 proteins are co-stimulatory ligands of certain T cells.

Immune response, Immune response regulation, Interleukin-10

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