Natural history of paroxysmal nocturnal hemoglobinuria
Article Abstract:
Paroxysmal nocturnal hemoglobinuria (PNH) can lead to shortened survival, though it also may go into spontaneous remission. PNH is a blood disorder that leads to death of blood cells and the formation of clots in veins. Researchers followed 80 people with PNH referred to a hospital between 1940 and 1970. The age range at diagnosis was 16 to 75 years, and the survival range after diagnosis was 0 to 48 years. Most of the patients had low platelet or low neutrophil counts at diagnosis. Seventy-two percent of the patient died within 25 years of diagnosis. Among the patients who died from a known cause, 58% died of a hemorrhage or blood clot caused by PNH. Fifteen percent of the patients experienced remission. Recommended treatment consists of preventative use of anticlotting drugs. The only way to cure PNH is with a bone marrow transplant, which can be dangerous. As a result, the chance of remission should be considered when deciding on bone marrow transplantation.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1995
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Paul Ehrlich's magic bullets
Article Abstract:
March 14, 2004, marks the 150th anniversary of the birth of Paul Ehrlich, one of the pioneers who laid the foundation of modern medicine. His theme 'magic bullet', that would specifically identify and destroy invading microbes or tumor cells is now not only a reality but a major aspect of clinical medicine.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
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Black morning, yellow sunsets - a day with paroxysmal noctural hemoglobinuria
Article Abstract:
The characteristics and symptoms of the disease paroxysmal nocturnal hemoglobinuria (PNH) are presented. The aftereffects of PNH are complement dependent intravascular hemolytic anemia, thrombosis and bone marrow failure.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
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